Pay-for-Performance Incentives: Holy Grail or Sippy Cup?

The Holy Grail of Advertising? Quality Signaling and Revenue Implications of "Pay- Per-Performance" Advertising

While there is a growing stream of research examining online sponsored search advertising, an important area that has not yet received enough attention is the interplay between pay-per-performance advertising and the quality of the firms who choose to invest in it. Our objective in this work is to explore how the shift from pay-for-exposure to pay-for-performance advertising affects the ability...

Bisphosphonates for osteoarthritis prevention: "Holy Grail" or not?

The search for effective disease modifying osteoarthritis (OA) agents has been a long and winding road with much unrealised promise. While a debate persists about whether OA is predominately a disease of bone, cartilage, or both, there has been interest in the possible OA disease modifying effects of bone antiresorptive agents including oestrogens, selective oestrogen receptor modulators, calci...

Searching for the Holy Grail?

Pursuing the "Holy Grail".

Over the past decade, several large, randomized trials have allowed us to better define the appropriate population for primary prevention implantable cardioverterdefibrillator (ICD) placement, saving thousands of lives every year. MADIT II (Multicenter Automatic Defibrillator Implantation Trial II) and SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) have demonstrated a survival benefit o...

Taxing Sugar-Sweetened Beverages: Not a “Holy Grail” but a Cup at Least Half; Comment on “Food Taxes: A New Holy Grail?”

In this commentary, we argue for the implementation of a sugar-sweetened beverage (SSB) tax as a tool to help address the global obesity and diabetes epidemics. Consumption of SSBs has increased exponentially over the last several decades, a trend that has been an important contributor to the obesity and diabetes epidemics. Prior evidence demonstrates that a SSB tax will likely decrease SSB con...